TEK and ischemia: Its antiangiogenic effect was firstly found on the chick embryo chorioallantoic membrane through inhibiting the mRNA expressions of bFGF, VEGF and VEGF‐F (flt‐1).36 Lately, Chen et al12 found that HSYA promoted angiogenesis via the angiopoietin 1/tie‐2 signalling pathway using HUVECs in vitro and a mouse hindlimb ischaemia model in vivo.