Tregs are well known to protect against the progression of asthma.26, 27 However, Tregs are also associated with autoimmune diseases such as rheumatoid arthritis, which is reminiscent of Th1/Th17‐driven inflammation.28 Moreover, TIGIT+ Tregs selectively suppress Th1/Th17 cell responses while sparing or even promoting Th2 cell responses. Here, TIGIT is linked to autoimmune disease.