Previous studies have revealed that TIGIT+ Treg subsets do not affect Th2 cytokine levels in mouse models of OVA‐induced allergic asthma.15 In addition, TIGIT stimulates Th2 cell differentiation through its interaction with CD155 to promote the development of allergic disease.16 Therefore, we investigated whether TIGIT is involved in selective regulation of Th2 responses. This evidence concerns the gene TIGIT and allergic disease.