To elucidate whether the selective inhibitory effects of DW2008S on Th2‐driven inflammation arise from TIGIT+ Th2 cell regulation or TIGIT+ Treg regulation, we evaluated the numbers of subsets of MLN TIGIT+ CD4+ T cells from mice with allergic airway inflammation.16 The total number of MLN TIGIT+ CD4+ T cells was significantly higher in the OVA asthma group than in the Normal group; however, it was normalized after DW2008S was administered to the animals (Figure 4A, B). Here, CD4 is linked to asthma.