Butz et al found that the relationship between TGF‐β and miRNAs biogenesis is an autoregulatory feedback loop, as many miRNAs may target a single gene, a single miRNA can target multiple genes.49 Also, in a study of lung cancer, the researcher found there is a negative regulatory model between the expression of miR‐193 and TGF‐β‐induced lung cancer.50 Down‐regulation of this miR could lead to increased production of TGFβ2, and its signal transduction could be further enhanced by the presence of increased TGFβR3. Here, TGFBR3 is linked to lung cancer.