In patients with initial brain lesions, the sensitivity, specificity, and positive and negative predictive values of MRI brain lesion distribution criteria were 79.8%, 87.5%, 90.4%, and 74.7%, when differentiating MS from NMOSD, and 79.8%, 100%, 100%, and 29.6%, when discriminating MS from MOG-EM, respectively. This evidence concerns the gene MOG and myeloid sarcoma.