An increase in PMP affects multiple cell signaling pathways and attributes to dysfunction of transcriptional factors.9 The development of symptoms and their exacerbation are directly related to the pattern of phenotypic expression of the genes referred to as gene-dosage effect.10 A deletion of the same gene (PMP22) results in hereditary neuropathy with liability to pressure palsy exhibiting a different type of neuropathy.11 The function of the PMP22 gene is likely to modulate myelin production, differentiation, and death. The gene discussed is PMP22; the disease is neuropathy.