The detection of anti-PLA2R1 antibodies in patients with nephrotic syndrome can be considered as a biomarker for the diagnosis of primary MN according to a recent meta-analysis (all study sensitivity 78% (95% CI: 66% to 87%) and specificity 99% (95% CI: 96% to 100%)) [6]. This evidence concerns the gene PLA2R1 and nephrotic syndrome.