Kang et al. analyzed CD161 expression and cytokine secretion in CD4+ T cells in blood and liver samples from patients infected with hepatitis C. They observed marked enrichment of CD161+CD4+ T cells in the liver during chronic hepatitis and a population of CD4+ T cells cosecreting IL-22 and IFN-γ [38]. The gene discussed is KLRB1; the disease is chronic hepatitis.