As outlined in Table 1, four members (Ib, IIa, IIc, and IIIb) of the Chinese family were found to have hypertension, hyperkalemia, hyperchloremic metabolic acidosis, suppressed renin–angiotensin–aldosterone system, and normal renal function, which were in accordance with the clinical characteristics of PHAII, and abnormal findings on laboratory examinations and hypertension were promptly normalized by the administration of thiazides. The gene discussed is REN; the disease is Hypertension.