Truncating and missense mutations of FOXC2 have been discovered in patients with late-onset lymphedema (hereditary lymphedema II; OMIM 153200), often associated with distichiasis (double row of eyelashes), and sometimes ptosis (Lymphedema Distichiasis Syndrome [LDS]; OMIM 153400), and/or yellow nails (OMIM 153300)7–9. This evidence concerns the gene FOXC2 and lymphatic malformation 5.