CD8A and neoplasm: An immune response to cancer occurs through a series of precise and stepwise actions beginning with tumour antigen presentation by antigen-presenting cells (APCs) and progressing through to priming and activation of T cells, trafficking of cytotoxic T cells (CD8+ cells) to tumours, and ultimately the killing of tumour cells.93 This interaction is regulated by immune checkpoints, which can be inhibitory or stimulatory.