Pre-clinical models have shown that microglia are capable of cross-presenting tumour antigens to CD8-positive T cells; microglia however, even when activated express less major histocompatibility complex (MHC) and co-stimulatory markers than similarly activated dendritic cells (DCs).103 Tumour-infiltrating DCs, macrophages, and pericytes are also candidates for antigen presentation within the tumour bed.104,105 Tumour antigens could also potentially drain outside the CNS to the peripheral lymphatics for antigen presentation. The gene discussed is HLA-C; the disease is neoplasm.