Then, we described an intensive correlation between CASC9 and LAMC2 expression in ESCC tissues, plus that LAMC2 overexpression could partially attenuate the decrease of cell migration and invasion capacity caused by CASC9 knockdown, providing sufficient evidence that LAMC2 was a target gene of CASC9. The gene discussed is CASC9; the disease is esophageal squamous cell carcinoma.