It has been reported that MALAT1 associates with EZH2 and enhanced methylation of H3K27 to downregulate genes in renal cancer cells [49]; on the other hand, MALAT1 upregulates EGFL7 by altering the level of H3 histone acetylation at EGFL7 promoter in gastric cancer [50]. This evidence concerns the gene EGFL7 and renal carcinoma.