TP53 and sarcoma: Interestingly, p73 protein exhibited a different accumulation pattern, with two peaks appearing at 4 and 24 hpi (Fig. 1a), which was also observed in p53-depleted H1299 human lung carcinoma cells, but not in Saos2 human osteogenic sarcoma cells lacking both endogenous p73 and p53 proteins (Fig. 1b).