Correspondingly, in animal models of multiple solid cancers, myeloid-restricted Gadd45b ablation restored pro-inflammatory tumour-associated macrophage (TAM) activation and intratumoural immune-cell infiltration, leading to TME-based tertiary lymphoid-structure (TLS) formation, reactivation of anti-tumour immune responses and diminished oncogenesis [6]. The gene discussed is GADD45B; the disease is neoplasm.