With regards to mRNA data for synaptophysin in the frontal cortex, one study reports a significant reduction in schizophrenia, while one reports a significant reduction in BAs 17 and 22 and a non-significant reduction in BAs 9 and 46, and two studies suggest no change in frontal cortex (Supplementary Table 1). The gene discussed is SYP; the disease is schizophrenia.