INS and Hypoglycemia: The principal findings of our study are as follows: (1) GLP-1RA showed the greatest effect on HbA1c reduction, followed by TZD, SGLT2i, and DPP4i; (2) the reduction in FPG was higher with SGLT2i than with DPP4i and GLP1-RA; (3) GLP-1RA and SGLT2i were associated with body weight reduction, whereas TZD increased body weight; (4) TZD and GLP-1RA reduced total daily insulin requirements; (5) the risk of hypoglycemia was increased with TZD and GLP-1RA.