The joint analysis showed a robust association between AS and rs7543130 (OR = 1.20; 95% CI: 1.16–1.25; P = 1.2 × 10−22) as well as rs1830321 (EAF[T] = 37.5%) intronic to TEX41, a non-protein coding gene on chromosome 2q22 (OR = 1.15; 95% CI: 1.11–1.20, P = 1.8 × 10−13) (Table 1). Here, TEX41 is linked to aortic valve stenosis.