Specifically, examining the impact of CAD-GRS-lip on the risk of AS among CAD cases shows that CAD cases with genetic predisposition to high Lp(a) or LDL/non-HDL cholesterol are at a greater risk of having AS than CAD cases without such predisposition (P = 8.5 × 10−7) (Supplementary Data 6). This evidence concerns the gene LPA and aortic valve stenosis.