Given the reported association between genetic predisposition to both elevated Lp(a) and low-density lipoprotein (LDL) cholesterol and AS6,19, we tested a subset of CAD-GRS (labeled as CAD-GRS-lip), constructed based on 14 Lp(a) and LDL cholesterol/non-high-density lipoprotein (HDL) cholesterol variants (Supplementary Data 4) for association with AS. This evidence concerns the gene LPA and aortic valve stenosis.