For example, depigmentation due to autoimmune melanocyte destruction is a common side effect of therapies targeting melanocyte differentiation antigens such as MART-1 and gp10038, and targeting of CD19 (a B cell-specific antigen) in leukemias results in conditions associated with loss of normal B cells, including lymphopenia and degammaglobulinemia5, 39. Here, CD19 is linked to lymphopenia.