TRAF3IP2 and neoplasm: One potential alternative to reconstitute host immunity is adoptive immunotherapy, which can eliminate cancer cells through transfusing in vitro expanded and activated immune cells, such as cytokine-induced killers (CIKs)13–16, natural killers (NKs)17,18, cytotoxic lymphocytes (CTLs), and tumor-infiltrating lymphocytes (TILs)19–21.