With regard to mtDNA sensors, King et al. [96] recently reported that mice genetically deficient in cGAS or STING exhibited impaired expression of IFN-stimulated genes, including Cxcl10. They also showed that interruption of IRF-3-dependent signalling leads to decreased expression of inflammatory cytokines and chemokines, attenuation of ventricular dilation, and improvement of cardiac function after myocardial infarction. This evidence concerns the gene CGAS and myocardial infarction.