We further analyzed the relationship between lncRNA-H19 SNPs haplotype and HCC risk and found that rs2735971-rs2839698- rs3024270 G-T-C significantly increased the risk of HCC (OR = 1.23, confidence interval (CI) = 1.01–1.51, P=0.043) (Table 3). The gene discussed is H19; the disease is hepatocellular carcinoma.