In this context, we report the development and validation of digital IA scoring methods that have been customized to profile multiple CD8 measures in whole-tumor sections of diffuse large B-cell lymphoma (DLBCL), gastroesophageal carcinoma (GEC), non-squamous (LNSQ) and squamous (LSCC) types of NSCLC, pancreatic carcinoma (PANC), primary prostate carcinoma (PROS), renal cell carcinoma (RCC), squamous cell carcinoma of the head and neck (HNSCC), and urothelial bladder carcinoma (UBC). The gene discussed is CD8A; the disease is diffuse large B-cell lymphoma.