The European Commission requested a scientific opinion from the European Food Safety Authority (EFSA) on the current knowledge of genetic resistance to TSE in goats [18], addressing, among others, the following terms of reference: “(1) Is there sufficient scientific knowledge available to have a robust level of scientific assurance that certain polymorphisms of PRNP present in European goat breeds confer genetic resistance to classical scrapie? This evidence concerns the gene PRNP and scrapie.