To investigate the importance of CITED2 and UPF1 in the biological function of miR-1468 in HCC cells, CITED2 or UPF1 was respectively restored in miR-1468-overexpressing Hep3B cells, and inhibited by corresponding siRNA in miR-1468-suppressive MHCC-97 L cells (P < 0.05, Fig. 6a). Here, UPF1 is linked to hepatocellular carcinoma.