Using a more general approach, a 25-mer CAG repeat morpholino oligos that binds CUGexp, injected into the muscle fibers of a DM1 mouse, can effectively displace the sequestered MBNL proteins from the CUG repeat RNA and restore the majority of the MBNL/CELF dependent splicing events, reversing the manifestations of myotonic dystrophy [204]. The gene discussed is MBNL1; the disease is myotonic dystrophy type 1.