TIPE3 and neoplasm: Tumor tissues from mice implanted with TIPE3-transfected A549 cells showed enhanced TIPE3 levels compared with those from mice implanted with mock-transfected A549 cells, and importantly, most of TIPE3 was localized in the plasma membrane of tumor cells (Fig. 7e), indicating TIPE3 located in plasma membrane could promote the proliferation of lung cancer cells in vivo.