The over-represented TF binding profiles that our analysis uncovered are associated with TFs involved in (i) neural development (SP2, ESR1, Creb5, SOX21) [53–56] and neurite outgrowth (KLF16, EGR3) [57, 58], (ii) cognitive functions (EGR3, EGR1) [59], (iii) craniofacial development (SP8) [60], (iv) proliferation of immune cells (EGR3, KLF5) [61, 62], platelet formation (SP3, SP1) [63] and innate immunological memory (ATF7) [64], (v) cell cycle control (E2F4) [65, 66] and tumor suppression (ZNF40, MZF1, TFAP2C, JDP2) [67–70], and (vi) reproductive functions (ESR1, Tcfl5) [54, 71]. The gene discussed is ESR1; the disease is neoplasm.