Subsequently, bovine pancreatic RNase A [12], bovine seminal RNase [13], Barnase [14], Ranpirnase (RNase I from Rana pipiens) [15], human pancreatic RNase 1 [16], human eosinophil-derived RNase (EDN) [17] and angiogenin (Ang) [18] all exhibit potent toxicity to cancer cells. This evidence concerns the gene RNASE1 and cancer.