ERBB2 and neoplasm: Menderes and co-workers [5] compared the anti-tumour activity of SYD985 against Trastuzumab emtansine (T-DM1), an ADC (which possess superior clinical activity against naked Trastuzumab due to the HER2 targeting effects of Trastuzumab and the antimicrotubular effect the DM1 portion) in ten primary OC cell lines with HER2 expression.