The MDMs, though generally susceptible to HIV-1 infection, are known to become relatively recalcitrant to HIV-1 upon stimulation with the Toll-like receptor 4 (TLR4) agonist polyinosine-polycytidylic acid (poly(I:C)) or Toll-like receptor 4 (TLR4) agonist lipopolysaccharide (LPC). This evidence concerns the gene TLR4 and HIV-1 infection.