COL18A1 and carcinoma: Endostatin has anti-angiogenic effect through the inhibition of proliferation and migration of vascular endothelial cells via inhibiting phosphorylation of focal adhesion kinase through binding integrin α5β1 or the antagonism of vascular endothelial growth factor receptor [35,36] Alahuhta et al. reported that endostatin induced proliferation of HSC-3 carcinoma cells, a human tongue squamous cell carcinoma cell line [37].