When supernatants from isolated KCs were tested for the induction of signature cytokines for inflamed skin by ELISA, we found that p(I:C) induced strong and comparable secretion of IL-6, TNF-α, and IL-8, regardless of whether unlabeled or labeled p(I:C) was used (Supplemental Fig. S1B). Here, CXCL8 is linked to dry eye syndrome.