ANXA2 and cancer: First, an accumulating observations have shown that Annexin A2 overexpressed in various types of cancer cells such as hepatocellular carcinoma (Zhang et al., 2012; Longerich et al., 2011; Sun et al., 2013), breast cancer (Deng et al., 2013; Chuthapisith et al., 2009; Shetty et al., 2012), lung cancer (Yao et al., 2009), gastric carcinoma (Zhang et al., 2012), pancreatic cancer (Takano et al., 2008), and colorectal cancer (Yang et al., 2013; Duncan et al., 2008).