Furthermore, signal transduction study has shown that Annexin A2 either promotes cancer cell metastasis by forming heterotetramer with S100A10 and binding with cell membrane (Réty et al., 1999), or largely enhances pro-survival capability and chemoresistance by activating transcription factors STAT-3 and nuclear factor-kappa B (NF-κB) (Tong et al., 2015; Jung et al., 2015). This evidence concerns the gene ANXA2 and cancer.