Herzog first described Lewy bodies in the superior cervical sympathetic ganglia in 1937,30 and the disease has been known to widely affect the peripheral autonomic nervous system for over 60 years.31 In the 1980s, the identification of Lewy bodies in the mesenteric plexus of the GI tract provided further evidence for a role of the autonomic system.32 Indeed, a widespread autonomic neuropathy characterized by synuclein-positive Lewy bodies and Lewy neurites is now generally considered an integral part of PD.33 This evidence concerns the gene SNCA and Parkinson disease.