PPAR-γ activators might have therapeutic potential, and studies conducted by Bai et al. [219] suggest that mediator 1 (MED1) is required for the PPAR-γ-induced M2 phenotype switch and showed that MED1 in macrophages has an antiatherosclerotic activity via PPAR-γ-regulated transactivation, suggesting MED1 as a promising target for atherosclerosis therapy. The gene discussed is PPARG; the disease is atherosclerosis.