It was found that miR-223 inhibits Pknox1, suppressing proinflammatory activation of macrophages, and protects against diet-induced adipose tissue inflammatory response and systemic insulin resistance [195]; miR-130b was found to be a novel regulator of macrophage polarization via repression of PPAR-γ and a promising target for T2D therapy [167]; miR-27a was also proposed as a target of intervention for inflammation and insulin resistance in obesity [196]. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.