CD40LG and HIV infectious disease: This report describes the results of a study designed to evaluate the seroconversion performance of the OraQuick ADVANCE® Test compared to automated IgG/IgM enzyme immunoassay (EIA) performance and to confirm the hypothesis that its Protein A-based detection system is able to detect samples known to be predominantly IgM positive, thereby demonstrating it is appropriate as a POC diagnostic test for acute HIV infection.