This implies that variation in tau protein aggregates is associated with different brain regions in different neurodegenerative disorders.114, 115 Mostly, tau pathology has been extensively studied as an “inter-disease phenomenon” shown in tauopathies including AD, frontotemporal dementia with Parkinsonism linked to chromosome-17, progressive supranuclear palsy, Pick’s disease, and cortico-basal degeneration.116–119 With the advancement in tau imaging ligands, it has been feasible to visualize different entities of tau aggregates in living patients with tau pathology. Here, MAPT is linked to progressive supranuclear palsy.