Decellularized zebrafish ECM, prepared from normal or healing hearts, was shown to enhance functional recovery and myocardial regeneration when administered into the peri-infarct region of a mouse model of MI, as well as having pro-proliferative and chemotactic effects on human cardiac precursor cells in vitro.49 The enhanced regenerative response in the mouse appeared to involve erbB2 signaling as it was abrogated by inhibiting erbB2 activity. Here, ERBB2 is linked to myocardial infarction.