One example is miR-7a, which inhibits adult mouse and human β-cell proliferation via inhibition of the mTOR pathway.174 Another example is miR-184, which targets Argonaute2, a component of the miRNA-induced silencing complex, to prevent murine β-cell expansion.175 Silencing of miR-184 during insulin resistance promotes expression of Argonaute2, which in turn, facilitates the function of miR-375 to decrease the expression of growth suppressors and promote compensatory β-cell proliferation to meet metabolic demands.175. Here, AGO2 is linked to Insulin resistance.