For example, Kcnip2 is known to be downregulated concomitantly with a reduction of Ito magnitude in cardiac hypertrophy.24,26 Our results are consistent with this finding for the previously studied 129 × 1/SvJ strain,24 but show that Kcnip2 is upregulated in many strains with pronounced hypertrophy leading to an overall positive correlation between Kcnip2 expression and heart mass FC. The gene discussed is KCNIP2; the disease is cardiac hypertrophy.