It is also interesting to note that the SAM module overlaps significantly (p = 3.4e-6, hypergeometric test) with a co-expression module previously found in post-ISO mice and shown to be involved in cardiac hypertrophy.38 Indeed, it shares the genes Timp1, Tnc, Mfap5, Col14a1 and Adamts2, the latter of which was validated experimentally as a regulator of cardiac hypertrophy. Here, TNC is linked to cardiac hypertrophy.