This is the case for the gene Kcnip2 encoding the protein KChIP2, which interacts with pore forming subunits (Kv4.2 and Kv4.3) of the transient outward current Ito expressed in heart, and which has been implicated in cardiac hypertrophy.23–25 Though not showing population-wide differential expression (Fig. 1f), its individual fold-change of expression can vary drastically from 2-fold decrease to a 2-fold increase depending on the considered strain (Fig. 1g). The gene discussed is KCND3; the disease is cardiac hypertrophy.