Inhibition of the activities of ER stress chaperones (GRP78 or prolyl 4-hydroxylase beta polypeptide, P4HB) has slowed cell growth, activated expression of CHOP and caspase 7 in TMZ treated cells, and enhanced GBM sensitize to TMZ treatment in vitro [53, 54]. The gene discussed is HSPA5; the disease is glioblastoma.