Considering the potential pathophysiological relevance of this loss of miR-758-3p in the progression of obesity to MetS, we also provide functional evidence that miR-758-3p targets CERP/ABCA1 in liver cells, in keeping with the reported higher CERP/ABCA1 mediated cholesterol efflux in MetS (in that case, compared to healthy controls). The gene discussed is ABCA1; the disease is obesity due to melanocortin 4 receptor deficiency.