Recently, Booth et al. reported that Pazopanib combined with PDE5i or ERBB1/2/4 inhibitor (afatinib) induced tumor cells (fresh PDX isolate of NSCLC) death via ER-induced stress by toxic autophagy and by affecting the chaperone activity in these cells an induction of ER stress-induced autophagy death [45]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.