In addition, novel molecular interactions with the cytoskeletal proteins TUBB and TUBB2A and the cytoskeletal regulator NME1 indicate a possible role for AIP as a regulator of cytoskeletal organization and on the integrity of the adherens junction, which might be a novel mechanism for the complex tumor suppressor function of AIP in the pituitary gland. The gene discussed is AIP; the disease is neoplasm.