PRMT6 and cancer: Statistical analysis of PRMT6 positivity and standard clinicopathological variables showed that the ratio of poorly differentiated, mucinous, and signet ring cells in the cell type was approximately two-fold higher in the group with PRMT6 expression (15.8%) than in the group without PRMT6 expression (7.2%) (p = 0.002), indicating that PRMT6 activity plays a critical role in cancer cell differentiation (Table 1).