These results are consistent with those of Nakakido et al. In contrast, DLD1 and HT29 cells did not show an increased ratio of p21 in the nucleus to cytoplasm under PRMT6-KD (Supplementary Figure 4B), suggesting that the regulation of p21 localization by PRMT6 is not a general phenomenon in CRC cells. The gene discussed is CDKN1A; the disease is colorectal carcinoma.