Remarkably, in Luminal A type, LMO2 related genes were specifically enriched in VEGF production, stemness, PPAR signal pathways and cell cycle regulation, indicating rationally oncogenic functions; whereas in Her2 type, the LMO2 related genes lacked the enrichment on many of the cancer-related pathways but particularly enriched in the negative regulation of ERBB-Ras-MAPK-ERK signal pathway, suggesting a largely tumor-suppressive effect of LMO2. Here, EGFR is linked to cancer.