Till now there still lacks systematic reports on LMO2 functions in breast cancer, in some of our preliminary studies [2, 17], we had demonstrated that LMO2 could attenuate the canonical Wnt-β-catenin pathway via binding with dishevelled-2 protein in a subtype-independent manner and specifically played a function of promoting tumor cell migration, invasion and metastasis via blocking on LIMK1-mediated phosphorylation of cofilin1 in basal type breast cancer. The gene discussed is LIMK1; the disease is breast cancer.