ERBB2 and invasive breast carcinoma: Within the Cancer Genome Atlas (TCGA) breast invasive carcinoma RNA_seq dataset including 113 normal and 1095 primary malignant breast tissue samples, general statistical analysis revealed that the average LMO2 expression level (FPKM value) in normal tissues was significantly higher than any of the 4 subtypes of breast cancer (ANOVA followed by Tukey’s test, p < 0.001), while among the 4 subtypes, only a slight higher LMO2 expression was found in Luminal A type compared with Luminal B type (Tukey’s test, p < 0.001) or Her2 type (Tukey’s test, p = 0.002) (Figure 1A).