BCL2 and cancer: Among these modified miR-129 mimics, we found that Mimic-2 and Mimic-3 are as good as the native miR-129 (data not show) in terms of inhibiting cancer cell proliferation and BCL2 expression, while Mimic-1 is the most potent miR-129 mimic at inhibiting colon cancer cell proliferation and target protein expression.