FLT3 and acute myeloid leukemia: Under the conditions where treatment with AZD1208 or GDC-0941 alone showed marginal effects, the effect of GDC-0941 to decrease the viable cell number was more prominently observed in the presence of AZD1208 than in its absence in 2 primary samples from FLT3-ITD-positive AML patients at diagnosis (Figure 6B; Case 1, 2), but not significantly in a sample from FLT3-ITD-positive AML patient at relapse (Case 3) or not at all in 2 samples without FLT3-ITD (Case 4, 5).