Finally, the combined inhibitory effects of AZD1208 and GDC-0941 on viable cell numbers and the mTORC1/Mcl-1 pathway were confirmed in primary leukemic cells from some patients with FLT3-ITD-positive AML, although the number of cases we could analyze was limited because of technical difficulties. This evidence concerns the gene FLT3 and acute myeloid leukemia.