FLT3 and acute myeloid leukemia: Because Pim kinases have been reported to be expressed downstream of STAT5 activation in FLT3-ITD-positive AML cells and implicated in upregulation of the mTORC1 pathway in various cell types, we have addressed in the present study the possible involvement of Pim kinases in acquisition of the resistance to PI3K/Akt pathway inhibitors by FLT3-ITD-expressing cells we have previously reported [21].