On the other hand, AZD1208 has previously been reported to inhibit proliferation of 5 of 14 AML cell lines, including MV4-11, with the inhibitory effect correlating with Pim-1 expression, STAT5 activation, and inhibitory effects of AZD1208 on mTORC1 activity [30]. This evidence concerns the gene PIM1 and acute myeloid leukemia.