More recently, Meja K. et al. [46] reported that the pan Pim kinase inhibitor AZD1897 and the Akt inhibitor AZD5363 synergistically inhibited proliferation of various AML cell lines, which correlated with downregulation of the mTORC1 activity and Mcl-1 expression. The gene discussed is MCL1; the disease is acute myeloid leukemia.