As detailed in Table 2, colon adenocarcinomas with low tumor IHC score were associated on univariate analyses with female gender, higher age, right location, high differentiation grade, mucinous type, Annexin A10 expression, loss of CDX2 expression, MSI-H status, BRAFV600E mutation, absence of KRAS mutation and CIMP-H. The gene discussed is CDX2; the disease is colon adenocarcinoma.