Using in vitro models, it has been demonstrated that LRP1 neutralization could abrogate cell motility in both tumor and non-tumor cells, and this despite an increase in pericellular proteolytic activities of several extracellular proteases such as MMP2 (Matrix Metalloproteinase 2), MMP9 and uPA (urokinase Plasminogen Activator) [20, 27]. This evidence concerns the gene PLAU and neoplasm.