LRP1 and neoplasm: As in our cohort, LRP1 mRNA expression levels among the TCGA cohort were significantly lower in cases with right tumor location (p = 0.0003), MSI-H (p < 0.0001), BRAF mutation (p = 0.0015) CIMP-H (p < 0.0001) and low CDX2 expression (p < 0.0001) (Figure 3D–3H).