LRP1 and neoplasm: LRP1 mRNA expression analyses by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) on 192 colonic adenocarcinoma samples and 105 colonic mucosa samples with RQI values ≥5 showed a 4.08-fold decrease in LRP1 expression within tumor samples when compared with normal colon samples (Figure 1A and 1B).