In order to identify genes and pathways whose inhibition synergizes with crizotinib to induce cell death in ALK rearranged non-small cell lung cancer, we performed a genome-wide RNAi-based synthetic lethal screen in two ALK+ NSCLC adenocarcinoma cell lines, H2228 and H3122 (Figure 1A). The gene discussed is ALK; the disease is non-small cell lung carcinoma.