In a double-blind, randomized and placebo-controlled study, treatment with 2150 mg resveratrol capsules twice daily for three months significantly reduced the levels of TNF-α, cytokeratin 18 fragment, and fibroblast growth factor 21 (FGF-21) and improved adiponectin level in NAFLD patients, suggesting its beneficial role in NAFLD [196]. This evidence concerns the gene FGF21 and metabolic dysfunction-associated steatotic liver disease.