Ryer et al. [26] previously conducted a methylation study on AAA in peripheral blood DNA using Illumina 450k micro-arrays and found differential methylation and gene expression in CNN2 and SERPINB9. In VSMCs, we also identified differential methylation in SERPINB9, but the relationship was converse to that seen in DNA isolated from peripheral blood. The gene discussed is SERPINB9; the disease is triple-A syndrome.